Heparin

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Heparin

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Should Bovine Heparin Reenter the US Market?

Although it was discovered in the early 1900s, unfractionated heparin (UFH) remains one of the most commonly used anticoagulants in clinical practice today.

UFH is a polysaccharide that exerts its pharmacologic activity by binding to antithrombin III (AT III) and interacting mainly with coagulation factors II and X.1 Similar agents include low-molecular-weight heparins like enoxaparin and dalteparin, which have shorter polysaccharide chains than UFH, and the pentasaccharide fondaparinux, which is a synthetic derivative of UFH that interacts only with AT III and coagulation factor X because of its lack of a long polysaccharide tail.

Heparin was first discovered in dog livers…

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Last Updated : Thursday, May 6, 2021