Abuse of the sedative suspected in Michael Jackson's death is a growing problem among medical professionals, increasing pressure on the government to restrict it as a controlled substance.
Three days before the pop icon's death on June 25, the American Association of Nurse Anesthetists warned hospitals to restrict access to the potent drug propofol because some doctors and nurses are addicted to it.
One addict fell asleep at his desk so often that his lolling forehead became a perpetual bruise. Another was so desperate for a fix that he started trolling through sharps bins for discarded needles with traces of drug to inject.
The addicts were two doctors, an anesthesiologist and a family physician. Their drug of choice: propofol.
Although healthcare providers have access to a wide array of potent narcotics, injectable propofol has become a drug of choice, and the most common reason for this is ease of access.
Propofol infusion syndrome (PRIS) is a rare, but potentially fatal, adverse effect of propofol administration. First described in children in 1992, and subsequently named by Bray in 1998, PRIS was classically defined as acute bradycardia progressing to asystole status post propofol administration...
Propofol killed Michael Jackson and may have played a role in death of comedian Joan Rivers.
It took a high profile case such as the death of Michael Jackson to bring worldwide attention to the misuse and dangers of Propofol. Access and availability should be restricted, a move than will save lives.
Propofol is given intravenously to induce anesthesia in surgical patients and to provide sedation for patients in the Intensive Care Unit. It's the most common induction agent of anesthesia in current use. It pretty much has replaced pentothal because it has fewer side effects and it makes people feel better when they wake up.
The major reason that propofol has become the induction agent of choice is that the traditional agent, a barbiturate called sodium thiopental, is no longer available,...
It turns out that propofol, used routinely for surgeries and procedures such as colonoscopies, has been a point of concern among some anesthesiologists because of the potential for abuse by health care workers.
My profession failed a national treasure, no matter how disordered, and failed him in pursuit of personal greed. We failed in his diagnosis, in his treatment, in disengaging from the dance with a manipulative addict and ultimately failed in the recognition of a critically important sleep disorder. Let us not fail in his wake to examine the lessons to found in the debris of destruction and share them with Americans everywhere.
The misuse and abuse of propofol among healthcare providers has been reported worldwide, with some misuse resulting in death. Propofol policies guiding healthcare worker re-entry into the workplace after misusing propofol have received rare attention in the research literature.
The King of Pop's doctor, Conrad Murray, is on trial for involuntary manslaughter, but could propofol alone have caused MJ's death? Harvard anesthesiologist Beverly Philip explains what gives this drug such lethal potential.
Propofol is a drug that was on trial as causing the death of the music icon. Guilt by association: not the doctor who administered the drug but for the propofol itself. Here is a perfectly fine anesthetic agent, minding its own business, being scrutinized just because it was in the wrong place at the wrong time.
DIPRIVAN Injectable Emulsion is an intravenous sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation. Intravenous injection of a therapeutic dose of propofol induces hypnosis, with minimal excitation, usually within 40 seconds from the start of injection (the time for one arm-brain circulation). As with other rapidly acting intravenous anesthetic agents, the half-time of the blood-brain equilibration is approximately 1 to 3 minutes, accounting for the rate of induction of anesthesia. The mechanism of action, like all general anesthetics, is poorly understood. However, propofol is thought to produce its sedative/anesthetic effects by the positive modulation of the inhibitory function of the neurotransmitter GABA through the ligand-gated GABAA receptors.
Propofol is mostly abused by health care staff including
anesthetists, practitioners, nurses and technicians.
Propofol is not scheduled under the Controlled Substances Act.
Intravenous, nonbarbiturate anesthetic.
Used for induction and maintenance of anesthesia and sedation of mechanically ventilated adult patients in the intensive care unit.
Induces anesthesia as quickly as thiopental with more rapid emergence.