Neonatal Sepsis

We accept risk in paediatrics every day. A 1% risk of missing a diagnosis might be fine on a child with a cough ?pneumonia, but many will see 1% as an unacceptable risk with a febrile neonate - Alasdair Munro & Damian Roland

Neonatal Sepsis
Neonatal Sepsis

image by: Emergency Kind

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Sepsis is uncommon in the term and late preterm neonates. Its estimated in 5 per 1000 cases, however it is 15% of all neonatal deaths.

Here, we define “term” as >37 weeks. Late preterm is 34-36 weeks. The earlier the gestational age, the higher the rates of neonatal sepsis. For purposes of workup, a late preterm neonate that did not have a complicated post-delivery course (prolonged NICU stay, comorbidities, etc) should be treated the same as a full term neonate.

Neonatal sepsis is defined as an infectious syndrome that occurs at any point during the period of birth to 28 days.

Sources: By far, the most common cause of fever in a neonate is some non-herpetic virus (adenovirus,…

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 Its just a virus? Tackling Pediatric Fever

Amp/Gent are preferred in the literature due to reports of emerging cephalosporin-resistant organisms. Also, cephalosporins are not active against Listeria. A few studies showed a lower mortality with Gentamicin compared to those treated with cefotaxime.

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