Augmentin (Amoxicillin-Clavulanate)

Widespread use of antibiotics promotes the spread of antibiotic resistance. Smart use of antibiotics is the key to controlling its spread - A. P. J. Abdul Kalam

Augmentin (Amoxicillin-Clavulanate)
Augmentin (Amoxicillin-Clavulanate)

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When should you prescribe amoxicillin clavulanate?

Most infections can be successfully treated with other types of antibiotics and amoxicillin clavulanate needs to be reserved for specific indications when it is really needed. The most common first-line indications for amoxicillin clavulanate are for human or animal bites or clenched fist injuries and for diabetic foot infections. Common secondline indications (after treatment failure with a narrow spectrum antibiotic) include mild acute pyelonephritis and acute sinusitis.

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 When should you prescribe amoxicillin clavulanate?

Amoxicillin clavulanate is an important and effective broad spectrum antibiotic that is used widely in general practice. The problem is not that it does not work, but rather the more it is used, the higher the likelihood that bacteria will become resistant to this drug.


The usual adult dose is one 500-mg tablet of AUGMENTIN every 12 hours or one 250-mg tablet of AUGMENTIN every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 875-mg tablet of AUGMENTIN every 12 hours or one 500-mg tablet of AUGMENTIN every 8 hours. Adults who have difficulty swallowing may be given the 125 mg/5 mL or 250 mg/5 mL suspension in place of the 500-mg tablet. The 200 mg/5 mL suspension or the 400 mg/5 mL suspension may be used in place of the 875-mg tablet.


Amoxicillin is the #1 prescribed antibiotic in the U.S. and among the top 20 medicines prescribed annually. And today, we’re the largest finished dosage form manufacturing facility for penicillin-class beta-lactam antibiotics—and the only U.S. FDA approved production site for Amoxil® and Augmentin® oral dose testing, manufacturing and packaging. At full capacity, we can produce billions of doses of American-made antibiotics on an annual basis.


The combination of amoxicillin and clavulanic acid is used to treat certain infections caused by bacteria, including infections of the ears, lungs, sinus, skin, and urinary tract. Amoxicillin is in a class of medications called penicillin-like antibiotics. It works by stopping the growth of bacteria. Clavulanic acid is in a class of medications called beta-lactamase inhibitors. It works by preventing bacteria from destroying amoxicillin.


Amoxicillin-clavulanate is a mainstay antibiotic in emergency departments and primary care offices throughout the country. It is a combination of two separate drugs: amoxicillin and clavulanic acid. Amoxicillin is a penicillin derivative and has a similar activity against both gram-positive and gram-negative bacteria. Furthermore, with the addition of clavulanic acid, the spectrum is increased to include beta-lactamase-producing strains as well as broadening the coverage to include other bacterial species.

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