Sartan Recalls

The safety of imported drugs has long been debated - Sheila Kaplan

Sartan Recalls

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Hypertension Hot Potato — Anatomy of the Angiotensin-Receptor Blocker Recalls

There's a chemical contamination story in the generic drug industry that just isn't going away... some lots of valsartan were recalled due to detection of N-nitrosodimethylamine (NDMA), and the problem has just continued since then...

That isn't good, because N-nitrosoamines are definitely genotoxic, at least at high levels. We're stepping off into a big toxicology argument at this point, because the genotoxicity of these things at lower levels is a matter for (heated) debate. It all depends on how the high-dose animal studies can be extrapolated down, how both high- and low-dose animal studies can be extrapolated to humans in general, and how to interpret human observational data…

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Last Updated : Friday, November 4, 2022