image by: Elizabeth Lemons
Oh, Coumadin, you little 5 milligram orange pill that runs my life, how I hate you. There are so many reasons why I disdain you so. Let me count the ways:
One, the reason I take you. I have a blood clot and because of my heart I am basically disposed to get clots. I shouldn’t hate you because you are supposed to stop new clots, but oh well. I hate you anyway.
Number two, Coumadin, is the way you taste. Terrible. Like, nauseatingly bad. I used to be able to swallow pills. In fact, I could do it without any water. But no more! I need water to choke you down.
Reason number three that we cannot be friends is the bruising. I know that I have chicken…
read full article
The Kcentra dosage calculator can save you time when determining the recommended dose of Kcentra for your patients.
This portable small size offers state-of-the-art features including Wi-Fi, Bluetooth®, Near Field Communication (NFC), and an easy to read color touchscreen. The system is designed for use in physician’s offices, laboratories, and patient home testing settings.
Home INR monitors are simple to use and provide accurate results. You don't need any medical experience or technology skills to perform the simple INR test. Real-time results allow immediate counselling and education without delay. All monitors are portable and include a carrying case.
Learn how monitoring your own INR can set you free.
DOACs have advantages over warfarin: they don't require regular blood tests, involve no food restrictions, and have fewer drug interactions. But, a major downside is cost, which is more than 20 times that of warfarin.
Acelis Connected Health’s mission is to support you every step of the way. Whether you’re just learning about warfarin for the first time, or you’re looking for delicious recipes that work with Vitamin K diets, this is the place for you.
As the label shown above, Kcentra contains all 4 Vitamin-K dependent coagulation factors (II, VII, IX and X), and the Proteins C and S. These are the clotting factors which are inhibited by warfarin. There are several advantages of using it...
If you have high blood pressure or heart disease, are taking diuretics or the blood thinner warfarin, or are pregnant or breastfeeding, your best bet is to avoid real licorice.
Warfarin is derived from coumarin, a sweet-smelling anticoagulant (blood-clotting) chemical found naturally in sweet clover and many other plants.
Sweet clover plant. Anita Gould/Flickr, CC BY-NC
In 1954, warfarin was approved for clinical use and has remained a popular anticoagulant ever since. Today warfarin is one of the most widely prescribed oral anticoagulant drugs with around 1-2% of adults in the developed world prescribed the medication.
Prior to its clinical application in the early 1950s, warfarin was used as a pesticide to kill rats and mice. It is still used for this purpose today.
Warfarin's efficacy in preventing embolic events in patients with atrial fibrillation (AF) has been proven and its mechanism understood (3,4). However, apart from patient's risk of bleeding when using it, Warfarin has several shortcomings...
Warfarin is metabolized by the cytochrome (CYP) P450 enzyme system, specifically, CYPs 1A2, 3A4, and 2C9.2 Medications that inhibit these CYP enzymes reduce warfarin's metabolism, increasing its effect, and increase INR. Medications that induce these CYP enzymes increase warfarin's metabolism, decreasing its therapeutic effect, and decrease INR. Medications can also directly affect the clotting cascade, induce warfarin's metabolism, or affect its protein binding.
Another very disheartening aspect of the EPA's ruling last week is that loose pellets of rat poison will still be available for sale in agricultural areas, though, only in large quantities. It is hard to understand the logic behind this.
Additionally, this ruling doesn't make mention of the first generation rodenticides, diphacinone, chloropacinone or warfarin which also cause the secondary and primary poisoning of wildlife and pets.
Warfarin is a compound of significant medical importance. Over the last 40 years, thousands have used it, and used it safely and effectively, to prevent strokes, heart attacks, clots in the legs (deep venous thrombosis), clots to the lungs (pulmonary emboli), and other disorders. It decreases the tendency of the blood to clot, and is very potent in doing so. It is a medication that must be taken with great care . . . it's not difficult, but it is important to "follow the rules" to maximize the benefits and minimize the potential adverse reactions.
Brodifacoum causes death in mice by thinning their blood so much that they hemorrhage. Products like d-Con mouse poison use brodifacoum because it doesn’t cause immediate death; as a result, mice are unable to associate the bait traps with their peers’ demise and keep going back for more. Also, because brodifacoum causes an unslakable thirst, mice often venture outside in search of water just before they die—which leaves homeowners with fewer rodent carcasses festering in their walls.
The main dietary concern of taking warfarin (common brand name: Coumadin) has to do with the amount of vitamin K in your diet. Vitamin K changes the way warfarin affects the blood. When you eat foods that are high in vitamin K, you can decrease the effect of warfarin. Likewise, eating less vitamin K can increase the effect of the medication.
The key is to try to eat a similar amount of foods that contain vitamin K each day. Don’t make any major changes to your diet without speaking with your doctor.
While taking Coumadin, it is necessary to consume consistent amounts of vitamin K in your diet. The daily adequate intake of vitamin K for adult males is 120 micrograms; for adult females the adequate intake is 90 micrograms per day, according to the Institute of Medicine.
Unlike most medications that are administered as a fixed dose, warfarin dosing is adjusted according to the INR blood test results; therefore, the dose usually changes over time. Coumadin/warfarin pills come in different colors, and each color corresponds to a different dose.
Dr Oterhals concluded: "Warfarin is a life saving drug but can be deadly if not used carefully. Health professionals have a responsibility to educate patients but unfortunately even cardiac nurses do not know enough. There is an urgent need to improve health professionals' warfarin knowledge so they can educate patients."
Some facilities fail to properly oversee Coumadin. Too much can cause bleeding; too little, clots. Nursing homes are “a perfect setup for bad things happening,” one expert says.
Some patients with an irregular heartbeat known as atrial fibrillation appear to have almost double the risk of a stroke in the first 30 days after starting treatment with warfarin — even though the anti-clotting drug is prescribed to prevent strokes, a study suggests.
Despite the new oral anticoagulants, warfarin remains the drug of choice, keeping the door open for point-of-care PT testing
Oh, Coumadin, you little 5 milligram orange pill that runs my life, how I hate you. There are so many reasons why I disdain you so. Let me count the ways...
If you do not find answers to your questions about warfarin, please send your question via e-mail to [email protected] and you will receive a response from a member of our editorial board.
Join the 'Coumadin' group to help and get support from people like you.
This is a place to connect with people who are taking Warfarin.
Commencing Warfarin therapy can be quite a shock; there is a lot to learn and many unexpected side effects to cope with, all while coming to terms with a diagnosis of a serious medical condition.
Share your frustrations, fears and hopes with others who understand what it's like.
This site has been created to help you understand COUMADIN. We encourage you to learn all you can about taking COUMADIN and to use the tools we've provided to work with your doctor to manage your treatment.
Extensive resource from FP Notebook.
Before using this medicine it's important to tell your doctor about all your previous health conditions as well as all the medications, including all prescription, non-prescription, illegal, recreational, herbal, nutritional, or dietary drugs that you are taking.
Although it will not dissolve blood clots that have already formed, warfarin may keep the clots from becoming larger and causing more serious problems.
Warfarin is commonly called a "blood thinner," but the more correct term is "anticoagulant." It helps to keep blood flowing smoothly in your body by decreasing the amount of certain substances (clotting proteins) in your blood.
While taking warfarin, your dose will be monitored once or twice a week using the international normalisation ratio (INR), which measures how long it takes your blood to clot. You may be monitored less frequently, depending on your readings.
Although there are now three new anticoagulants that don’t require regular monitoring – rivaroxaban, apixaban and dabigatran – most patients who need an anticoagulant will be prescribed warfarin.