Sodium channel blockers

To recall all class I antiarrhythmic medications, think of ordering a burger at a restaurant: “Double Quarter Pounder with Lettuce, Mayo, Pickles, and Fries, Please!” - Anonymous

Sodium channel blockers
Sodium channel blockers

image by: South Kashmir Paramedical & Nursing College Kulgam

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Class I antiarrhythmic agents

Specifically, the drugs of interest here are the Class I agents by Vaughan Williams classification, a group of membrane stabilisers which are united by their common mechanism of effect, which is interference with the fast sodium current in cardiac myocytes...

Though it appears that virtually everybody has at some stage published a paper or written a blog post about Class I agents, it was remarkably difficult to track down enough information about the origins and mechanisms of their unique electrophysiological properties. What is offered here was pieced together from several sources, none of which could be recommended independently, as each has substantial shortcomings.

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 Class I antiarrhythmic agents

Though it appears that virtually everybody has at some stage published a paper or written a blog post about Class I agents, it was remarkably difficult to track down enough information about the origins and mechanisms of their unique electrophysiological properties. What is offered here was pieced together from several sources, none of which could be recommended independently, as each has substantial shortcomings.

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