The underrated, unloved liver performs more than 300 vital functions. No wonder the ancients believed it to be the home of the human soul - Natalie Angier
image by: American Liver Foundation
Facing a Silent Liver Disease Epidemic
For most people, the acronym NASH won’t ring any bells. But NASH, or nonalcoholic steatohepatitis, is stealthily showing up in the livers of millions of Americans. Marked by the accumulation of an unhealthy amount of fat and scar tissue in the liver, NASH is quietly reaching epidemic proportions across the globe.
By 2020, NASH is projected to overtake hepatitis C as the leading cause of liver transplants in the U.S. The disease is poised to win that dubious honor because an alarming rise in obesity and type-2 diabetes—key risk factors for NASH—is coinciding with far better treatments for hepatitis C.
Despite NASH’s prevalence, its obscurity isn’t surprising: It doesn’t…
A Big, Fatty Opportunity for Big Pharma
The next big opportunity for pharmaceutical companies is in a disease many people don’t know about. Investors and industry observers should expect to hear a lot about nonalcoholic steatohepatitis, or NASH, in the coming year. Treating this severe form of fatty liver disease is a massive business opportunity, but investors will need patience for promise to develop into profits.
Fatty liver disease: What it is and what to do about it
There are lots of medical terms related to fatty liver disease, and it can get confusing. The main medical umbrella term NAFLD refers to a fatty liver that is not related to alcohol use. NAFLD is further divided into two groups: Non-alcoholic fatty liver (NAFL), otherwise known as simple fatty liver, or Non-alcoholic steatohepatitis (NASH)
Is Fatty Liver Disease the New Diabetes?
Horton says those who are prediabetic or are overweight or obese should especially take notice of this study, given that fatty liver disease is so closely associated with the two.
The Effects of Physical Exercise on Fatty Liver Disease
The increasing prevalence of obesity has made nonalcoholic fatty liver disease (NAFLD) the most common chronic liver disease. As a consequence, NAFLD and especially its inflammatory form nonalcoholic steatohepatitis (NASH) are the fastest increasing etiology of end-stage liver disease and hepatocellular carcinoma.
To Fight Fatty Liver, Avoid Sugary Foods and Drinks
Children with fatty liver disease sharply reduced the amount of fat and inflammation in their livers by cutting soft drinks, fruit juices and foods with added sugars.
Treatment for obesity and fatty liver disease may be in reach
Researchers have discovered 27 new molecules. These molecules all activate a special protein called PPAR-delta and have the potential to treat fatty liver disease, obesity, diabetic nephrotoxicity, and to heal wounds.
Nonalcoholic Fatty Liver Disease & NASH
Usually, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) cause few or no symptoms. Certain health conditions—including obesity, metabolic syndrome, and type 2 diabetes—make you more likely to develop NAFLD and NASH.
Looming Epidemics: Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH)
“It is imperative to understand that NAFLD and NASH are conditions that cannot be taken lightly. The damage to the liver is a real medical problem that in many cases can be life threatening. What is even more alarming is that victims of this disease typically do not even know they have it—in fact, it can go undetected for years. Therefore, bringing awareness to the condition within the community is of utmost importance.”
Does My Liver Look Fat in This?
“Non-alcoholic fatty liver disease is currently the most common liver disease in most of the Western world, affecting 30 percent of adults and 10 percent of children — and this number is growing,” warns Tamar Taddei, M.D., associate professor of medicine, section of digestive diseases at the Yale School of Medicine and a member of the American Liver Foundation’s medical advisory committee.
Unchecked, the disease can lead to liver transplant and possible fatality. The good news is that in the vast majority of cases, fatty liver can be managed, or even reversed, through a few simple action steps.
Fatty Liver Disease: More Prevalent in Children
The disease's prevalence is alarming doctors who worry about its progression to nonalcoholic steatohepatitis, or NASH, when the fatty liver becomes inflamed and cells are damaged. That leads to the end stage of cirrhosis, when the liver forms scar tissue and ultimately stops working.
Fatty Liver Is More Dangerous Than You Might Realize. Here’s How to Heal It
What’s so bad about having a fatty liver? Well, among its numerous repercussions include inflammation, which triggers insulin resistance and pre-diabetes, meaning your body deposits fat in your liver and organs including your belly (called visceral fat).
The Invention of an Illness
Fatty liver disease has gone from unknown to pandemic, but does it mean anything?
Threat Grows From Liver Illness Tied to Obesity
Despite major gains in fighting hepatitis C and other chronic liver conditions, public health officials are now faced with a growing epidemic of liver disease that is tightly linked to the obesity crisis.
What's the Big Deal About a Fatty Liver?
For those patients who have been diagnosed with non-alcoholic fatty liver disease, it is the leading cause of chronic liver disease in the United States and other Western countries.
Why fatty liver disease is on the rise
Fatty liver disease was once seen mostly in heavy drinkers. Now, at least a third of adults in Canada have it—and it’s hard to diagnose
Facing a Silent Liver Disease Epidemic
As nonalcoholic steatohepatitis, or NASH, stealthily becomes a leading cause of transplants, drug companies race to develop treatments.
Fatty Liver Diary
Everything about fatty liver, from somebody who managed to reverse NAFLD
The NASH Education Program
The NASH Education Program aims to increase awareness about Non-Alcoholic SteatoHepatitis (NASH). Our mission is to address unmet needs in the field of awareness, via educational initiatives targeting physicians from all relevant medical specialties, as well as patients diagnosed and individuals at risk of developing the disease.
NAFLD is a non-specific title describing several variations of the disease with differing levels of severity. In simple NAFLD, there are no symptoms, only steatosis, which is an excess of triglycerides in the liver.
As research into this spectrum of conditions remains inconclusive, there are no UK guidelines yet developed and uncertainty shrouds many important issues, including prevalence, diagnosis and treatment. Therefore, at this time the priority in management is lifestyle modification and addressing cardiovascular and metabolic risk factors.
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Last Updated : Tuesday, June 11, 2019