There is no conclusive evidence of benefit in terms of recovery to normal visual acuity, visual field or contrast sensitivity six months after initiation with either intravenous or oral corticosteroids at the doses evaluated in trials included in this review.
Optic neuritis is an inflammatory condition of the optic nerve characterized by a sudden onset of unilateral visual loss, usually affecting young females. Demyelination associated with multiple sclerosis (MS) is the most common cause in regions where MS is prevalent; while in other places, there are a substantial proportion of cases where infective or autoimmune causes are seen.
Optic neuritis is one of the symptoms of which those of us who live with multiple sclerosis on a daily basis know can set us apart from others.
Many cases of optic neuritis resemble MS in their pathophysiology, and are believed to be autoimmune in nature.
OK – Here’s part 2 in my Optic Neuritis story. This is how my health care providers have been “providing care.”
High-dose IVCS are effective in hastening visual recovery in acute typical optic neuritis, but do not affect the final visual outcome. In optic neuritis patients, IVCS may delay progression to clinically definite multiple sclerosis (CDMS) at 2 years, but not at 5 or 10 years. It is reasonable to recommend high-dose IVCS for acute optic neuritis patients with significant vision loss, severe pain and/or white matter lesions on brain MRI in whom the potential for benefit outweighs the risks.
My story: dealing with doctors,optic neuritis, and the effects of high dose steroids.
The Optic Neuritis Foundation, Inc. is determined to increase symptom recognition, augment public awareness, raise funds to support research and provide financial and/or resource assistance to individuals receiving the diagnosis.
The Guthy-Jackson Charitable Foundation is dedicated to funding research to understanding the pathophysiology and biochemistry of NMO.
You are in the right place if you or someone close to you, is affected by Leber’s Hereditary Optic Neuropathy (LHON), or you are a medical professional interested in LHON.
Optic neuritis usually causes a reduction or loss of vision in at least one eye. For many people with optic neuritis, vision typically gets worse over a period of several days to two weeks and then begins to improve.
Optic neuritis usually gets better on its own.
The most common cause of ON is inflammatory demyelination of the optic nerve. The pathology (similar to that of acute MS) involves plaques in the brain, with perivascular cuffing, edema in the myelinated nerve sheaths, and myelin breakdown. Similar to MS, a genetic susceptibility for ON is suspected, and it is believed that the demyelination in ON is immune-mediated. However, the specific mechanism and target antigen(s) are unknown..
Most people who have a single episode of optic neuritis eventually recover their vision. Treatment with steroid medications may speed up vision recovery after optic neuritis.
Vision often returns to normal within 2 to 3 weeks with no treatment.
Corticosteroids given through a vein (IV) or taken by mouth (oral) may speed up recovery. However, the final vision is no better with steroids than without. Oral steroids may actually increase the chance of recurrence.
ADON is a common cause of ON in parts of the world where multiple sclerosis (MS) is common. However, there are many other possible causes which must not be overlooked, as they may require different and urgent management.
Optic neuritis usually presents with the acute onset of monocular eye pain and vision loss in a young adult. Pain is usually associated with eye movements and often precedes loss of vision. Patients often report having had similar events in the same or fellow eye.