Is There Still Value in Prescribing Metronidazole for C Difficile Treatment?

In 2017, the Infectious Disease Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA) published their updated clinical practice guidelines giving first-line therapy designation to vancomycin or fidaxomicin for all C difficile infections, thus supplanting metronidazole as the indicated therapy of choice.

Flagyl (Metronidazole) Toxicity

I created this blog for one simple purpose—to help people who have had a serious, adverse reaction to Flagyl (aka, metronidazole), so they have a place to read about the condition and to find answers to questions that no medical professional was willing to help me find.

C diff Guidelines: Metronidazole Still Preferred?

In what other diseases do we recommend something different for mild vs. severe infection, when both are oral options? I understand there is a cost difference, but since the data on treatment of severe CDI demonstrate the superiority of vancomycin, is this the right approach? Especially since oral vancomycin is better tolerated?

Disulfiram-like Reaction with Metronidazole

While taking metronidazole it is advised that patients avoid ethanol use for at least 3 days after therapy due to the possibility of a disulfiram-like reaction. The disulfiram-like reaction presents as abdominal cramps, nausea, vomiting, headaches, and/or flushing and can cause extreme discomfort for patients.

End Of The Line With Metronidazole For Clostridium difficile Infection?

Metronidazole (Flagyl) has been one of the most commonly used antibiotics for Clostridium difficile infection for years, but there has been a shift in recommendations lately. Is this the end of the line with metronidazole for Clostridium difficile infection? An infectious diseases pharmacist provides insights here.

Exploring Metronidazole Toxicity: A Video Series

In 2015, I suffered an adverse reaction to the antibiotic, metronidazole (also called Flagyl), which triggered a whirlwind of dysfunction across my body – everything from muscle twitches and head pressure to losing the ability to walk and speak. In total, I had roughly forty random symptoms and most of them did not resolve after discontinuation of the medication.

Metronidazole resistance: a hidden epidemic?

Metronidazole resistance can occur by a number of different mechanisms that involve reduced uptake of the drug, increased removal from the bacterial cell or by reducing the rate of metronidazole activation inside anaerobes.

Metronidazole Side Effects: Everything You Need To Know

If you suffer from Bacterial Vaginosis (also known as BV), you’ve probably heard of Metronidazole. This prescription-only antibiotic is extremely effective at treating BV — and Metronidazole side effects are also very uncommon. Although the risk of encountering Metronidazole side effects is usually low, it is always worth finding out more about any medication and how it could potentially affect you before starting any course of treatment.

Metronidazole – is it safe to use with breastfeeding?

The balance of current evidence and clinical experience, and the consensus of specialist opinion, is that there is no established mutagenic or carcinogenic risk to infants breastfeeding from mothers receiving routine short-course treatment with metronidazole by any route.

New Study Recommends 7 Days of Metronidazole for Trichomoniasis

For more than 30 years, the standard treatment for trichomoniasis, which affects about 143 million women globally each year, has been a single dose of the antibiotics metronidazole or tinidazole.

Pharm 101: Metronidazole

Potent activity against anaerobes, including Bacteroides and Clostridium species.

Uses and abuses of Flagyl

Metronidazole is a strong antibiotic that becomes rapidly effective within an hour or two after being taken. It can be taken with food, water, or on an empty stomach. If a patient finds that the drug upsets the stomach, then it can be taken with milk or a meal.

Why a Common Antibiotic Treating Diarrhea is Failing – Metronidazole Resistance Examined

C. diff doesn’t go down easily. After 30 years, the most commonly prescribed antibiotic used to fight it, metronidazole, known commonly by the brand name Flagyl, is no longer as effective as it used to be. Now researchers want to know why and what genetic changes are occurring to cause this resistance in efforts to identify new drug targets to stop the bacteria.

Why I Caution the Use of the Antibiotic Flagyl (Metronidazole) for SIBO and C. difficile Infections

If you have to take Flagyl, I would recommend that you supplement with some thiamine and magnesium during taking the antibiotic and afterward for a few weeks in the hope that toxicity symptoms do not occur.