Sulfonylureas

Except for insulin, sulfonylureas and biguanides are the best studied and most widely used glucose-lowering agents. However, neither class of drugs has had an easy life because of concern about safety - Matthew C. Riddle

Sulfonylureas
Sulfonylureas

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Sulfonylureas for Patients with Type 2 Diabetes: Still an Option

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 Sulfonylureas for Patients with Type 2 Diabetes: Still an Option

Prescribing of sulfonylureas, generally as add-on therapy when metformin alone does not achieve adequate glycemic control in patients with type 2 diabetes, has been decreasing in recent years.

ScienceDirect

SUs are predicted to promote insulin secretion via multiple mechanisms, including binding to the SUR1 subunit of β-cell K+ATP channels and activation of Epac2, a cAMP binding protein that triggers the activation of Rap1.

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