Glitazones

All that glitters is not gold - Proverb

Glitazones
Glitazones

image by: Diabetes Queensland

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Diabetes drug pioglitazone could get personal: Neither panacea, nor peril

When I was in training, one of my beloved mentors declared, “I never use a drug until it’s been on the market for 20 years.” I was young enough then that I couldn’t fathom being a doctor for 20 years, let alone waiting two decades to use a new drug. As my career has progressed, I’ve seen many new drugs released to the market. Some of them are truly miraculous, bringing people longer, healthier, and more productive lives. Many of them have not withstood the test of time. More than a few have even been taken off the market. Even though the Food and Drug Administration diligently reviews each new medicine before it’s approved for use, we often learn much more about a drug after its release into…

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 Diabetes drug pioglitazone could get personal: Neither panacea, nor peril

When they were first released, these medicines were widely accepted and adopted. We do, after all, have an epidemic of obesity and diabetes in the United States, and they seemed to work very well for people. They seemed a great alternative to insulin, which has to be injected. Then, after about 6 years on the market, these drugs began to be linked to liver disease and congestive heart failure

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... the use of TZDs in the US and Europe has declined significantly due to safety concerns.

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