Neuroblastoma
Rare is one of those strange words that can have exactly opposite meanings, depending on what you are describing. It can be beautiful, like a precious gem carved from rugged stone. But it can also be very, very ugly, like Stage 4 neuroblastoma - Isabella Santos Foundation
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Neuroblastoma: A Tough Nut to Crack
Because of the heterogeneous biology of neuroblastoma, its clinical behavior and prognosis range from near uniform survival to high risk for fatal demise. Significant advances in our knowledge of neuroblastoma biology have led to improved prognostic stratification and appropriate tailoring of therapy, although our evolving molecular understanding has yet to translate fully into novel therapies.
Resources
It Started With A Girl…
On March 9th, 2005, Isabella Joanne Santos came into the world. Her first two years were filled with memories and milestones just like every other child. In the summer of 2007, she began to complain of frequent back and stomach pain. After months of misdiagnosis, an MRI revealed a tumor in her abdomen and showed the disease had spread to her bone marrow. On October 4, 2007, she was diagnosed with stage 4 Neuroblastoma.
Neuroblastoma
In the discipline of pediatric cancer biology, neuroblastoma signifies an oncologic conundrum given the clinical range with which it presents. Prognosis correlates with age and the degree of differentiation, and thus, outcomes vary from high rates of survival (with even possible tumor regression) to recurrence and mortality. While the standard of treatment is chemotherapy, radiation, and/or surgical resection, there is growing evidence that aggressive neuroblastomas are resistant to our therapies.
Study Confirms Dinutuximab Extends Life for Children with High-Risk Neuroblastoma
Neuroblastoma is a childhood cancer of immature nerve cells. It’s rare, with only 800 children diagnosed each year in the United States, mainly infants and those under 5 years old. The disease is called high-risk when it has certain features that indicate it is aggressive, such as if it has spread from its original location. Approximately half the children diagnosed each year have high-risk disease.
Warrior Walt & his Battle with Stage IV High-Risk Neuroblastoma
Walt, 22 months old, was diagnosed with stage IV high-risk neuroblastoma on July 24th, 2019. Walt and his family are Native Americans, part of the Lac du Flambeau Band of Lake Superior Chippewa Indian Tribe in Wisconsin.
Neuroblastoma: A Tough Nut to Crack
Neuroblastoma is undoubtedly one of the most enigmatic tumors, with remarkable heterogeneous clinical behavior ranging from spontaneous regression to metastatic disease that is refractory to therapy.
Isabella Santos Foundation
Neuroblastoma can begin anywhere in the body, but is most commonly found in the adrenal gland, located on top of the kidney. Other common locations for neuroblastoma include the neck, chest, abdomen, and pelvis, near the spine. Neuroblastoma can spread to other areas of the body, including the bone marrow, bones, and lymph nodes. Neuroblastoma usually occurs in infants and young children. It is uncommon in older children and teenagers. About 7 out of every 100 children with cancer will have neuroblastoma.
Neuroblastoma Australia
We believe every child diagnosed with neuroblastoma deserves to grow up and lead a long and healthy life
Neuroblastoma Blog
Blog about neuroblastoma biology.
Neuroblastoma Info
From diagnosis to treatment and beyond, here you’ll find the information you need to help guide you and your child along their treatment journey.
Neuroblastoma UK
Wanting there to be more positive outcomes for children with neuroblastoma is the reason why we at Neuroblastoma UK work here.
The Neuroblastoma Children’s Cancer Society
The mission of the Neuroblastoma Children’s Cancer Society is to cure neuroblastoma and its related childhood cancers, as well as to improve the quality of life for patients, survivors, and their families.
Children with Cancer UK
Neuroblastoma is the most common form of embryonal tumour. Embryonal tumours are characterised by the proliferation of tissue that is normally only seen in the developing embryo. They are mainly seen in very young children.
ACCO
Neuroblastoma is a solid cancer of the nerve tissue of the sympathetic nervous system. It often begins in the adrenal glands, which are small glands on top of each kidney. It can also begin in the chest, in nerve tissue near the spine in the neck, or in the spinal cord.
Cancer.net
Clinical trials are underway to study the use of chemotherapy combined with immunotherapy, tyrosine kinase inhibitors, or other drugs. Researchers hope that these drug combinations will increase the effectiveness and decrease the side effects of induction treatment.
Cancer.org
Neuroblastoma is a cancer that starts in certain very early forms of nerve cells, most often found in an embryo or fetus. (The term neuro refers to nerves, while blastoma refers to a cancer that starts in immature or developing cells). This type of cancer occurs most often in infants and young children.
EyeWiki
Neuroblastoma is a tumor of neural crest origin, and primarily affects children. It is the most common extra-cranial solid tumor in children. It frequently metastasizes to the orbit, and ocular signs and symptoms may be the first presentation of the tumor.
StatPearls
Neuroblastoma (NB) is the most frequently-occurring extracranial childhood tumor. It is classified as an embryonal neuroendocrine tumor, originating from neural crest progenitor cells. Hence, it can occur anywhere along the sympathetic nervous system, including the superior cervical, paraspinal, and celiac ganglia; the majority arise in the adrenal glands.
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