Many malaria prophylaxis options, but none perfect - Stacey Butterfield


image by: Cell & Molecular Biology

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Malaria: Targets and Drugs for All Stages

Unfortunately, resistance frequently arises to any widely-used single drug. In the last five years, strong gains were made through combinations such as artemisinin-combination therapies (ACTs) where artemisinins were combined with a partner to which resistance had emerged. But now there are signs of resistance to artemisinins, the spread of which would wipe out recent gains. However in HIV, three drug combinations and first, second and third line combinations are being used to win the fight against AIDS. Malaria has proved a challenge, but there is hope; compared to viruses, the parasites’ mutation rate is lower and disease management is relatively straightforward. Thus expanding the existing…

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 Malaria: Targets and Drugs for All Stages

Malaria is an ancient enemy. Its treatments predate modern drug discovery, most notably the use of the Qinghao plant in ancient China (2nd century BC to 340 CE) and Peruvian bark in the early 17th century, the medicines from which are now known to be artemisinin and quinine respectively.

Chloroquine, Past and Present

Chloroquine's fame is as an antimalarial drug, and the history of antimalarials starts of course with quinine. That's the active compound in cinchona bark, whose medicinal properties had long been known among the natives of South America in the tropical parts of the Andes - the Incas and the people(s) that the Incas absorbed into their empire. It doesn't seem to have been used by them as a malaria treatment per se, but rather was known as a treatment for shivering, brought on by either low temperatures or by malaria itself.

Medicines for Malaria Venture

Our mission is to reduce the burden of malaria in disease-endemic countries by discovering, developing and facilitating delivery of new, effective and affordable antimalarial drugs.

Push Health

Malaria prophylaxis, sometimes referred to as malaria prevention medication, consists of specific medications that reduce the risk that one will contract malaria if exposed to it while traveling. Push Health can connect people in need of a malaria medication prescription with local medical providers who can prescribe malaria pills if it is safe and appropriate to do so.


No antimalarial drug is 100% protective and must be combined with the use of personal protective measures, (i.e., insect repellent, long sleeves, long pants, sleeping in a mosquito-free setting or using an insecticide-treated bednet).


Malarial chemoprophylaxis functions by targeting the liver schizont, blood schizont, or hypnozoite stages of the plasmodium life cycle. The three most commonly prescribed medications for chemoprophylaxis are atovaquone-proguanil, doxycycline, and mefloquine.

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