Innate Immunity
Because of the intricate nature of the immune system, the innate system also provides cues in the forms of chemical signals (cytokines) or degraded products of infectious organisms (antigens) to activate the adaptive immune system - Raj Thaker
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image by: Biology Concern
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Show Your Immune System Some Love
Unlike antibodies, which can zero in on specific pathogens, innate immune cells are built to clobber just about anything that doesn’t resemble their human host. Perhaps it’s no surprise that these underdog cells are often forgotten or outright snubbed in conversations about immune protection.
But the all-purpose approach of innate immune cells has its charms. They’ll try anything at least once, and they’re admirably selfless. When pathogens come knocking, innate cells are the first to volunteer to fight, and often the first to die (RIP, neutrophils). Some ambush invading microbes directly, snarfing them down or bathing them with deadly toxins, while others blow up infected cells—tactics…
Resources
Innate immunity: the first line of defense against SARS-CoV-2
Improved understanding of how the innate immune system detects and responds to SARS-CoV-2 will help identify targeted therapeutic modalities that mitigate severe disease and improve patient outcomes.
Innate Lymphoid Cells (ILCs): Guardians Against Infection
Innate lymphoid cells are the most recently discovered innate immune cells. Hints of their existence emerged during the 1970s —by way of research on natural killer (NK) cells and lymphoid tissue inducer (LTi) cells— but a fuller characterization of the family didn’t arrive until the late 2000s.
Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics
Our innate immune response represents the first line of defense against invading pathogens. Clinically, the fever that is often the first symptom of a viral infection is also the first manifestation of our antiviral defense system in action. Moreover, for 95% of all species—including plants and all invertebrate animals—innate immune responses are the only protection available. Only vertebrates developed lymphocytes to mediate adaptive immune responses.
The Immune System's First Responders Are Smarter Than We Thought
New research shows that the immune system’s first responders are much more specialized and work better together than once thought. The findings could lead to the development of new antibiotics, and may also help explain why some people are more susceptible to particular types of infections.
The Science Behind Why Children Fare Better With Covid-19
Children’s innate immune systems help fend off the virus more effectively than those of adults.
Innate And Adaptive Immunity In The Human Intestine
Only recently have researchers come to realize that one of the major defenses against infection, especially in the gut, but also elsewhere, is mediated by a family of innate immune cells known as innate lymphoid cells (ILCs). In this series, we focus on one particular subset of this family, group 3 innate lymphoid cells (ILC3s), which have some remarkable and unexpected properties.
Innate immune system
The innate immune response is the first mechanism for host defense found in all multicellular organisms. The innate immune system is more ancient than the acquired or adaptive immune response, and it has developed and evolved to protect the host from the surrounding environment in which a variety of toxins and infectious agents including bacteria, fungi, viruses and parasites are found
Innate vs Adaptive Immunity
Organisms must constantly protect themselves from harm caused by pathogens like viruses and bacteria. The immune system delivers this protection via numerous pathways. The immune response is broken down into innate immunity, which an organism is born with, and adaptive immunity, which an organism acquires following disease exposure.
The innate and adaptive immune systems
The immune system is made up of two parts: the innate, (general) immune system and the adaptive (specialized) immune system. These two systems work closely together and take on different tasks.
Show Your Immune System Some Love
Innate immune cells might be convenient dates, for a time. But while they’re great at first impressions, they can also be commitment-phobes, as likely to ghost you as they are to come on strong. (Besides, who wants to date someone who’s always arriving on the early side?)
ScienceDirect
Innate immunity is an evolutionary old defense system that generates a fast inflammatory response that is generic to all types of pathogens or tissue damages and does not confer immune memory to the host.
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