Osteomalacia
Osteomalacia remains quite common. When the disorder presents with fractures, bone pain, and reduced bone mineral density (BMD), it may masquerade as osteoporosis - Robert S. Weinstein & Prasuna Madhavaram
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image by: Abu Dhabi University (ADU)
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Rickets and Osteomalacia
Rickets and osteomalacia are diseases with multiple etiologies primarily related to abnormal metabolism of vitamin D and secondarily to calcium and phosphate metabolism. Of the many causes, by far the most important relate to dietary vitamin D deficiency and the activation of vitamin D precursors by the kidney and sunlight. Rickets and osteomalacia are characterized pathophysiologically by a failure of normal mineralization of bone and epiphyseal cartilage and clinically by skeletal deformity. Rickets occurs in growing infants and children, and both bone and epiphyseal cartilage are affected. Osteomalacia occurs in adults after closure of the epiphyses, and its manifestations are often much…
Resources
Medical mystery: The pain gripped his left ankle. Within months, it was spreading
... she thought he was suffering from tumor-induced osteomalacia (TIO), a bone-weakening disease caused by one or more typically benign, slow-growing tumors. These tumors produce high levels of a protein called fibroblast growth factor 23 (FGF23), which limits the ability of the kidneys to absorb phosphate. The first signs of the disease, also known as oncogenic osteomalacia, include fractures, bone pain and muscle weakness — all symptoms Gajavelli had reported.
Are you sure your patient has Osteomalacia and what should you expect to find?
Osteomalacia remains quite common. When the disorder presents with fractures, bone pain, and reduced bone mineral density (BMD), it may masquerade as osteoporosis but in striking contrast to osteoporosis, osteomalacia usually has abnormal levels of serum calcium, inorganic phosphorus, or alkaline phosphatase activity.
Nutritional Rickets and Osteomalacia in the Twenty-first Century: Revised Concepts, Public Health, and Prevention Strategies
Nutritional rickets and osteomalacia are common in dark-skinned and migrant populations. Their global incidence is rising due to changing population demographics, failing prevention policies and missing implementation strategies.
Osteomalacia and Vitamin D Deficiency in the Elderly
Vitamin D deficit may cause osteomalacia, which should be included in the differential diagnosis for fractures caused by minimal trauma. It is suggested that Vitamin D assays should be included in routine assessments of the elderly and that Vitamin D supplementation should be considered even in tropical countries.
Rickets and osteomalacia
Rickets is the clinical consequence of impaired mineralization of bone matrix throughout the growing skeleton, whilst osteomalacia is the result of this disturbance after the growth plates have fused in adults.
Vitamin D Deficiency Causes Osteomalacia and Rickets
In children, Rickets is easily detectable as the disorder tends to cause pronounced skeletal deformities. In adults Osteomalacia is difficult to diagnose as it is difficult to differentiate it from osteoporosis.
Vitamin D Deficiency including Osteomalacia and Rickets
Adequate vitamin D3 by synthesis in the skin and from dietary and supplemental sources is essential for bone health throughout life. Rickets in children and osteomalacia in adults are the classic but extreme manifestations of severe vitamin D deficiency
Rickets and Osteomalacia
Rickets and osteomalacia are diseases with multiple etiologies primarily related to abnormal metabolism of vitamin D and secondarily to calcium and phosphate metabolism.
DynaMed
Osteomalacia is a bone disease that occurs due to severe vitamin D, phosphate, or calcium depletion, and is characterized by unmineralized or poorly mineralized osteoid.
MayoClinic
The dull, aching pain associated with osteomalacia most commonly affects the lower back, pelvis, hips, legs and ribs. The pain might be worse at night or when you put pressure on the bones. The pain is rarely relieved completely by rest.
MedlinePlus
Osteomalacia is softening of the bones. It most often occurs because of a problem with vitamin D, which helps your body absorb calcium. Your body needs calcium to maintain the strength and hardness of your bones. In children, the condition is called rickets.
NHS
Rickets is a condition that affects bone development in children. It causes bone pain, poor growth and soft, weak bones that can lead to bone deformities. Adults can experience a similar condition, which is known as osteomalacia or soft bones.
Patient
Adequate vitamin D3 by synthesis in the skin and from dietary and supplemental sources is essential for bone health throughout life[1]. Rickets in children and osteomalacia in adults are the classic but extreme manifestations of severe vitamin D deficiency.
StatPearls
Vitamin D deficiency accounts for the most common nutritional deficiency among children and adults. Osteomalacia describes a disorder of “bone softening” in adults that is usually due to prolonged deficiencies of vitamin D. This results in abnormal osteoid mineralization. In contrast, rickets describes deficient mineralization at the cartilage of growth plates in children.
You and Your Hormones
Osteomalacia literally means soft bones (from the Greek language, ‘osteo’ meaning bone and ‘malakia’ meaning softness).
ZerotoFinals
Patients with osteomalacia are likely to have risk factors such as darker skin, low exposure to sunlight, live in colder climates and spend the majority of their time indoors.
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